Laboratory of Biophysics and Bioinformatics
Address:Laboratory of Biophysics and BioinformaticsNeuroscience InstituteLithuanian University of Health SciencesEiveniu st. 4Kaunas LT-50161Lithuania
Phone: +370 37 302966
Head of the laboratory:
Prof. Algimantas Kriščiukaitis, PhD, email@example.com
Asta Kybartaitė-Žilienė, PhD, firstname.lastname@example.org
Aušra Saudargienė, PhD, email@example.com
Paulius Čižas, PhD, firstname.lastname@example.org
Robertas Petrolis, PhD, email@example.com
Laboratory short history
Laboratory of Biophysics and Bioinformatics was founded in 1990. Its origins go back to 1972, when in the Laboratory of Electrical Stimulation and Defibrillation of the Heart, the research group on electrophysiological was created. In 1982 on the base of cardiac electrophysiology research group the Laboratory of Cardiorythmology and Electrical Stimulation was founded. In 1990 the latter part of the laboratory staff has established Laboratory of Biophysics of Excitable Systems (recent – Laboratory for Biophysics and Bioinformatics).
Objectives of laboratory were: investigations of myocardial passive and active properties under normal conditions and under ischemia, investigation of intercellular communication mechanisms on the single channel level and mathematical modelling of intercellular communication; and evaluation of functional properties of viable tissues and systems: biophysical modelling based multivariate analysis of multimodal biomedical data.
Title: Evaluation of functional properties of viable tissues and systems: biophysical modelling based multivariate analysis of multimodal biomedical data
Recent advances in electronics and information technologies opens new possibilities of multimodal registration of acoustical, and electrical signals and optical images in extraordinary variety of spectral bands comprehensively reflecting valuable diagnostical information in multimodal way about wide range of objects, starting from isolated cells, through tissues, organs till systems of whole organism. Effective usage of such possibilities using advanced imaging and mathematical information processing methods opens the way for breakthrough in most actual areas of healthcare. Effective diagnostics, prevention and control of age related degenerative processes in human body could be achieved using biophysical models based imaging and quantitative evaluation methods.
Researchers of Laboratory for Biophysics and Bioinformatics, having sufficient experience and basic technological resources are planning to elaborate biophysical models based biomedical signal and image analysis methods able to detect pathological changes in living tissues and systems, evaluate interrelations of several concurrent processes causing pathogenesis of the diseases. It is planned to create: a specialized methodology for elaboration of tissue structure/pattern evaluation methods; methodology for usage of multivariate analysis for multimodal signals and images; strategies for elaboration of biophysical models based multimodal signal and image analysis for functional properties of organs and systems in human body.
The work will be performed in collaboration with Laboratories of Ophthalmology and Biochemistry, Department of Neurology, and Institute for Digestive Research.
2019-2020 – a Partnering Project "Multiscale Hippocampal Models for Neuronal Plasticity: Integration to the Brain Simulation Platform - HippoPlasticity" to the Human Brain Project (HBM) Flagship, head dr. A.Saudargienė
2019 – a project "Scientific visit at the Center for Memory and Brain, Boston University, US", funded through the Research Council of Lithuania, head dr. A.Saudargienė
2018-2022 – EU funded COST Action project CA17121 COMULIS "Correlated Multimodal Imaging In Life Sciences", prof. A.Kriščiukaitis
2018-2022 – collaboration (prof. A.Kriščiukaitis) in the ESF funded project No 01.2.2-LMT-K-718-01-0030 „Personalized wearable technologies for evaluating life-threatening health conditions in chronic kidney disease patients”, head prof. V.Marozas (KTU)
2018-2019 – a project "Mobile internet application for mindfulness based cognitive behavioural therapy", funded by the Research Council of Lithuania, head dr. A.Saudargienė
2018 – the Baltic-German University Liaison Office project "Synaptic and dendritic dysfunction in Alzheimer‘s disease: computational and experimental neuroscience perspectives to understand the dynamics of neurodegenerative processes", funded by the German Academic Exchange Service (DAAD) with funds from the Foreign Office of the Federal Republic Germany. The aim of the project is to investigate complex interactions of hippocampal CA1 pyramidal neuron deficient cholinergic neuromodulation, synaptic dysfunction and dendritic atrophy due to beta-amyloid peptides accumulation in Alzheimer’s disease applying computational modelling approach. Project leader dr. A.Saudargienė.
2016-2018 – contribute (dr. A.Saudargienė) in the EC programme Horizon 2020 funded project ID 650003 “EU FET Flagship Human Brain Project”
2015-2018 – collaboration (prof. A.Kriščiukaitis) in the project No MIP-15045 “The Impact of focused trasthoracic echocardiography in urgent abdominal surgery for septic patients”, funded by the Research Council of Lithuania, head prof. A.Macas
2013-2015 – collaboration in post doc (dr. Asta Kybartaitė-Žilienė) project BioMONDA "Multimodal data analysis of optic nerve and it's environment based on biophysical models", funded by Research Council of Lithuania, head prof. A.Kriščiukaitis
2013-2015 – collaboration (prof. A.Kriščiukaitis) in the ESF funded project No VP1-3.1-ŠMM-10-V-02-004 “Smart wearable monitoring system for human healthcare”, head prof. A.Lukoševičius (KTU)
2010-2011 – collaboration in the project No MIP-68/2010 „Multivariate analysis based non invasive evaluation of central haemodynamics and prognosis of patient status”, funded by the Research Council of Lithuania, head prof. A.Kriščiukaitis
Université de Rennes 1, France; Pontifícia Universidade Católica do Rio Grande do Sul / Microgravity Centre, Porto Alegre, Brazil; Albert Einstein College, NY, USA; State University of New York, USA; University of Michigan, USA; Free University of Berlin, Germany.
2018 - 2011 main publications
Updated on 9 September 2019
Laboratory of Biochemistry
Address:Laboratory of BiochemistryNeuroscience InstituteLithuanian University of Health SciencesEiveniu st. 4Kaunas LT-50161Lithuania
Phone: +370 37 302968
Head of the laboratory:
prof. Vilmantė Borutaitė, PhD, firstname.lastname@example.org
prof. Ramunė Morkūnienė, PhD, email@example.com
prof. Sonata Trumbeckaitė, PhD, firstname.lastname@example.org
prof. Rasa Banienė, PhD, email@example.com
Daiva Majienė, PhD, firstname.lastname@example.org
Julius Liobikas, PhD, email@example.com
Odeta Arandarčikaitė, PhD, firstname.lastname@example.org
Kristina Škėmienė, PhD, email@example.com
Paulius Čižas, PhD, firstname.lastname@example.org
Silvija Jankevičiūtė, PhD, email@example.com
Katryna Pampuščenko, PhD student, firstname.lastname@example.org
Zbigniev Balion, PhD student, email@example.com
Danielius Umbrasas, PhD student, firstname.lastname@example.org
Title: The investigation of cell death and protective mechanisms in models of brain ischemia, neurodegenerative and other diseases
Protein aggregates containing beta amyloid (Aβ) and other multimeric proteins are critical factors in the pathogenesis of neurodegenerative diseases (including Alzheimer's disease) by causing synaptic dysfunction, neuronal death and loss. Molecular mechanism by which protein aggregates cause death of brain cells and activation of neuroimmune processes will be investigated. Alongside, search and investigation of possible pharmacological modulators of the processes involved will be performed.
The study also will focus on mechanisms of ischemic mitochondrial damage in brain tissue. The possible sites of ischemic damage in mitochondria will be determined and the possible protective pharmacological agents against ischemic mitochondrial injury will be tested. In the frame of the Global Grant project, cultures of human inducible pluripotent stem cells will be introduced as a model to investigate how human cells die and how to protect them from ischemic damage. A wide comparative analysis of effects of ischemia and reperfusion on immature, mature and aging brain cells (neurons, astrocytes and microglia) will be performed to test whether potential inhibitors of mitochondrial permeability transition pore can protect against ischemia-induced cell death or inflammatory responses in the brain and help to restore functional activity of neurons.
We are going to determine which compounds (synthetic and natural), acting separately or in combination with pharmacological compounds, are able to suppress viability of brain cancer cells, mitosis/interphase cycle, proliferation and migration of cells in the model systems. We are planning to reveal possible molecular mechanisms of action of those compounds in model systems. We expect that obtained data will pave the way for the in vivo studies on mice glioma allograft and human/mice xenograft models, and will allow us to confirm and specify in vitro data.
The Laboratory has expertise in primary neuronal and transformed cell cultures; cell biology; potentiometric methods using oxygen, nitric oxide and ion-selective electrodes; spectroscopy, fluorescent microscopy, protein chemistry, DIGE, etc.
2018-2020 – contribute (prof. S.Trumbeckaitė, dr. J.Liobikas) in the project No J05-LVPA-K-03-0117„Promotion of UAB AKVAVITA Investment in R&D Activities for the Development of Innovative Products in the Beverage Industry“, managed by Lithuanian Business Promotion Agency, head prof. V.Jakštas
2018-2020 – contribute (prof. R.Banienė) in the project No J05-LVPA-K-01-0220 „Promotion of UAB "Birštono mineraliniai vandenys" Investment in R&D Activities for the Development of Innovative Products“, head prof. V.Lesauskaitė
2018-2020 – collaboration (prof. S.Trumbeckaitė, prof. R.Banienė) in the project No BN 18-255 "Effect of Farming Systems on the Accumulation of Biologically Active and Anticancer Compounds of potato tubers with Coloured Flesh”, funded by Ekhagastiftelsen Grant Foundation Program (Sweden), head prof. E.Jarienė (ASU)
2018-2020 – Lithuania–Japan collaboration program project NO LJB-18-2 “Investigation of molecular factors of Alzheimer’s disease: link between extracellular tau, beta-amyloid and neuroinflammation”, funded by the Research Council of Lithuania, head prof. R.Morkūnienė, participants prof. V.Borutaitė, K.Pampuščenko
2017-2021 – Global grant project No LMT-K-712-01-0131 "Dissecting ischemic brain injury: role of mitochondrial permeability transition pore in cells of developing and aging brain", head prof. V.Borutaitė
2017-2021 – EU funded COST Action project CA16225 “Realising the therapeutic potential of novel cardioprotective therapies” (EU-CARDIOPROTECTION), prof. V.Borutaitė, dr. O.Arandarčikaitė
2016-2020 - EU funded COST Action project MITOEAGLE “Mitochondrial mapping: Evolution - Age - Gender - Lifestyle - Environment", prof. V.Borutaitė
2016 m. – project No PR16-82 "Imaging of live tissue/models' mimetics", supported by Joint Stock Company Ferentis, dr. A.Jekabsone
2015-2018 – collaboration (prof. S.Trumbeckaitė) in the project No SEN-01/2015 „Optimizing the effectiveness of Hyperthermic chemotherapy by modulation of heat shock proteins, energy resources and adhesion in malignant cells“, head prof. A.Gulbinas
2015-2016 – collaboration in the EU Horizon 2020 project No 664339 HEALTH-TECH “Centre of Excellence in Science and Technology for Healthy Ageing", prof. V.Borutaitė
2015 – project No VP2-1.3-ŪM-02-K-04-016 "Investigation of interaction of cells with customer's prototypic hydrogel samples in vitro", managed by Lithuanian Business Promotion Agency, dr. A.Jekabsone
2013-2015 – EU funded COST Action project FA 1005 INFOGEST "Improving health properties of food by sharing our knowledge on the digestive process", dr. J.Liobikas, dr. S.Trumbeckaitė
2012-2015 – contribute (dr. S.Trumbeckaitė) in the Global grant project* No VP1-3.1-ŠMM-07-K-02-062 "Energetic, genetic and epigenetic mechanisms of resistance to chemotherapy induced apoptosis in pancreatic cancer", head prof. Ž.Dambrauskas
2012-2014 – a project No LIG-04/2012 MALPAMA "Molecular mechanisms of pathogenesis of Alzheimer’s disease” (n collaboration with Institute of Biochemistry, and Institute of Biotechnology of Vilnius University, Department of Neurology of Lithuanian University of Health Sciences Hospital), funded by Research Council of Lithuania, dr. R.Morkūnienė
2012-2014 – ESF funded project No VP1-3.1-ŠMM-08-K-01-022 „Implementation of R&D activities of Medicine National Research Programmes in clinical and molecular research of fundamental cardiology, neurosciences, and digestive systems“, dr. G.Svirskis, prof. V.Borutaitė
2012-2014 – contribute (dr. S.Trumbeckaitė) in the project No LIG-12002 STELLATA „Investigation of activity and redox status of Pancreatic Stellate Cells", funded by the Research Council of Lithuania, head prof. G.Barauskas
2011-2015 – Global grant project* No VP1-3.1-ŠMM-07-K-01-130 “Mitochondria, nitric oxide and cytochrome c reducing agents in protection against brain and heart ischemia-reperfusion injury”, head prof. V.Borutaitė
2011-2014 – a project No SVE-11008 HIBRIDAI „Interspecific hybrids of orchard plant – a novel source of anthocyanins“, funded by the Research Council of Lithuania, head dr. J.Liobikas
2010-2011 – a project No MIP-10182 "The evaluation of biological activity and technological functionalization of lectins", dr. J.Liobikas, dr. D.Majienė
2008-2010 – a project AMILOIDE “Detection of pathogenic beta-amyloid oligomers for diagnostics of Alzheimer’s disease”, funded by Lithuania State Science and Studies Foundation, head prof. V.Borutaitė
2007-2011 – EU funded COST Action project FA0602 MITOFOOD (A research community for nutritional optimization of mitochondrial function for health promotion and disease resistance), Lithuania deputy prof. V.Borutaitė
2006-2009 – EUREKA project E! 3694 PROPOCREAM „The development of the multifunctional semisolid preparations from natural products“, dr. D.Majienė
2006-2007 – EC 6FP Marie Skłodowska-Curie project No MERG-CT-2006-044907 MITOCHONDRIA & ABETA (Mitochondria and beta-amyloid in brain ischemia/reperfusion), dr. A.Jekabsone
2004-2006 – EC 6FP Marie Skłodowska-Curie project No CT-2004-010313 MITOCHONDRIA (Role of nitric oxide/oxygen competition at mitochondria in neuronal death during ischemia and/or inflammation), dr. A.Jekabsone
The Laboratory participates in a project of the Advanced Pharmaceutical and Health Technologies Centre of Lithuanian University of Health Sciences. The researchers have access and are actively using open access facilities of the Laboratory for Pharmacological Regulation of Pathological Processes and Research of Drug Metabolism.
Dr. Guy Brown, Department of Biochemistry, University of Cambridge, UK
Dr. Erich Gnaiger, Department of General, Visceral and Transplant Surgery, Daniel Swarovski Research Laboratory, Innsbruck Medical University, Innsbruck, Austria
2018.06.01-08.31 – Erasmus+ programe funded PhD student Katryna Pampuščenko traineeship at Cambridge University (UK), Department of Biology, head prof. Guy C. Brown
2017.10.01-11.30 – MITA supported dr. Silvija Jankevičiūtė traineeship at the Stem Cell Laboratory for CNS Disease Modeling, Lund University (Sweden)
Other important information
In 2012, prof. V.Borutaitė was awarded with Osvalds Šmidebergs Medal of Latvian Society of Pharmacology.
In 2008, prof. A.Toleikis, prof. V.Borutaite, prof. V.Mildaziene (former member of the laboratory) were awarded with Lithuanian National Price for Science.
Members of the Laboratory in collaboration organized the 4th MiPsummer School on Mitochondrial Physiology in Druskininkai, Lithuania on June 10-16, 2010.
2018 - 2011 main publications
Updated on 22 May 2019
Laboratory of Behavioral Medicine
Address:Laboratory of Behavioral Medicine (Kaunas)Neuroscience InstituteLithuanian University of Health SciencesEiveniu st. 4Kaunas LT-50161Lithuania
Phone number: +370 37 326164
Head of the laboratory:
Julius Burkauskas, PhD, email@example.com
Adomas Bunevičius, PhD, MD, firstname.lastname@example.org
Aistė Pranckevičienė, PhD, email@example.com
Ramūnas Jokubka, PhD, firstname.lastname@example.org
Violeta Žaliūnaitė, PhD, email@example.com
Miglė Kaminskaitė, PhD student, firstname.lastname@example.org
Mindaugas Urbonas, PhD student, email@example.com
Julius Neverauskas, PhD, firstname.lastname@example.org
Giedrė Žalytė, email@example.com
Address:Laboratory of Behavioral Medicine (Palanga)Neuroscience InstituteLithuanian University of Health SciencesVyduno al. 4/ Sliupo st. 7Palanga LT-00135Lithuania
Narseta Mickuvienė, PhD, firstname.lastname@example.org
Julija Brožaitienė, PhD, email@example.com
Giedrius Varoneckas, PhD, firstname.lastname@example.org
Vesta Steiblienė, PhD, email@example.com
Aurelija Podlipskytė, PhD, firstname.lastname@example.org
Arvydas Martinkėnas, PhD, email@example.com
Vaidutė Gelžinienė, PhD, firstname.lastname@example.org
Laima Sapežinskienė, PhD, email@example.com
Vilija Jakumaitė, PhD, firstname.lastname@example.org
Alicja Juškienė, PhD, email@example.com
Dalia Martinaitienė, PhD, firstname.lastname@example.org
Nijolė Kažukauskienė, PhD, email@example.com
Audrius Alonderis, PhD, firstname.lastname@example.org
Vilma Liaugaudaitė, PhD student, email@example.com
Saulius Taroza, PhD student, firstname.lastname@example.org
Julija Gečaitė, PhD student, email@example.com
Adelė Grinevičienė, firstname.lastname@example.org
Violeta Augustinienė, email@example.com
Laima Eidukienė, firstname.lastname@example.org
Virginija Jasienė, email@example.com
Jolanta Kvietkauskienė, firstname.lastname@example.org
Elena Bovina, email@example.com
Nijolė Raškauskienė, firstname.lastname@example.org
Alė Vonsavičienė, email@example.com
Rytis Sapežinskas, firstname.lastname@example.org
Laboratory was established in 2011, and currently involved in research of neurodegenerative diseases. In 2018, after reorganisation, got the name of Laboratory of Behavioral Medicine.
Title: Neuroendocrine and psychological prognostic biomarkers in brain disorders
Brain disorders are often incurable and debilitating diseases associated with progressive disability and poor prognosis. The prognostic value of currently available clinical prognostic models remains sub-optimal and should be improved in order to allow more accurate assessment of disease severity, clinical outcomes and patient-oriented outcomes. Certain psychological (i.e., psychological distress) and neuroendocrine (i.e., thyroid hormones) factors can be important biomarkers of outcomes in brain disorders; however, further studies aiming to elucidate the prognostic value of these prognostic factors are warranted. Patient-oriented outcomes are becoming increasingly used when evaluating treatment efficacy and patient prognosis, especially among patients suffering from incurable and debilitating disorders, such as brain tumours.
The main goal of our Laboratory is to identify novel neuroendocrine and psychological markers associated with disease severity, clinical sequalea and patient-oriented outcomes of patients suffering from brain disorders.
These findings can potentially improve accuracy of currently available prognostic models and open new avenues for developing more effective treatment strategies of brain disorders.
2018-2019 – a project "Mobile internet application for mindfulness based cognitive behavioural therapy" funded by the Research Council of Lithuania, head dr. A.Saudargienė
2018 – a project on training mental health profossionals No PR18-108, funded by State Mental Health Centre, head dr. V.Steiblienė
2018 – LSMU-VDU funded project "Genetic predisposition to alcohol addiction and associated personality traits GVPRAVSAB", head dr. R.Jokubka
2017-2021 – EU funded COST action project CA16207 "Problematic Internet Use", managament committee members dr. A.Bunevičius, dr. J.Burkauskas
2017-2020 – collaboration (V.Liaugaudaitė, A.Juškienė) in the project No S-MIP-17-257 "Psychosocial suicide risk factors and accessibility of help in the environment of persons’ who committed suicide", funded by the Research Council of Lithuania, head prof. N.Žemaitienė
2015-2018 – a project No MIP‐15482 BRAINflame "Psychological distress, inflammatory factors, brain natriuretic peptide and outcomes of patients with brain tumor", funded by by the Research Council of Lithuania, head dr. A.Bunevičius
2012-2019 - collaboration (dr. A.Bunevičius) in a project BioASQ “A challenge on large-scale biomedical semantic indexing and question answering”, funded by EC 7FP (Grant Agreement No 318652, 2012-2014), National Library of Medicine of the National Institutes of Health (award No R13LM012214, 2014-2018), and Google Funding (2018-2019), head dr. G.Paliouras, NCSR Demokritos, Greece
2012-2016 – EC 7FP project No 318652 OpenScienceLink: Open Semantically-enabled, Social-aware Access to Scientific Data, habil.dr. R.Bunevičius (2012-2014), dr. A.Bunevičius
2013-2015 – The Global grant project* No VP1-3.1-ŠMM-07-K-02-060 „Gene-Environment Interactions Connecting Low Triiodothyronine Syndrome and Outcomes of Cardiovascular Disease (GET-VASC)”, head habil.dr. R.Bunevičius (2012-2014), habil.dr. J.Brožaitienė (2014-2015)
2012-2014 - a project No LIG-03/2012 "Relations among heart diseases, psycho-emotional and sleep disturbances; their impact on life quality", funded by the Research Council of Lithuania, head prof. G.Varoneckas
2011-2013 – a project No LIG-03/2011 "Impact of mental disorders and metabolic syndrome on mortality in primary health care patients", funded by the Research Council of Lithuania, head habil.dr. R.Bunevičius
2011 – a project No LIG-04/2011"Factors determining quality of life and outcomes in patients with ischemic heart disease", funded by the Research Council of Lithuania, head dr. N.Mickuvienė
2010-2013 – EU funded 7FP project “A challenge on large-scale biomedical sematic indexing and question answering BioASQ”, Lithuania deputy habil.dr. R.Bunevičius
2010-2013 – EU funded 7FP project No 247945 “Efficient Patient Recruitment for Innovative Clinical Trials of Existing Drugs to other Indications PONTE”, Lithuania deputy habil.dr. R.Bunevičius
2018.07.01-- 2019.06.29 – dr. Adomas Bunevičius traineeship at Harvard University, Department of Neurosurgery, Brigham and Women’s Hospital, Boston, Massachusetts, USA
Prof. Edward R. Laws, Harvard University, Department of Neurosurgery, Brigham and Women’s Hospital, Boston, Massachusetts, USA
Prof. Giorgio Iervasi, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy
Prof. Susan S. Girdler, Department of Psychiatry, University of North Carolina at Chapel Hill, USA
Prof. Charles B. Nemeroff, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA
Prof. Victor JM Pop and Pof. Johan Denollet, Center of Research on Psychology in Somatic diseases (CoRPS), Department of Medical and Clinical Psychology, Tilburg University, The Netherlands
The European College of Neuropsychopharmacology. Please contact us at: http://facebook.com/ltecnp and http://twitter.com/ltecnp
2018 - 2011 main publications 2017 - 2010 main publications of Behavioral Medicine Institute
Updated on 20 September 2019
Laboratory of Molecular Neurobiology
Address:Laboratory of Molecular NeurobiologyNeuroscience InstituteLithuanian University of Health SciencesEiveniu st. 4Kaunas LT-50161Lithuania
Phone number: +370 37 302967
Head of the Laboratory:
Paulina Vaitkienė, PhD, email@example.com
prof. Ilona Sadauskienė, PhD, firstname.lastname@example.org
Aistė Jekabsone, PhD, email@example.com
Rasa Bernotienė, PhD, firstname.lastname@example.org
Arūnas Liekis, PhD, email@example.com
In 1976, a group of scientists in Department of Biological and Bioorganic Chemistry began to study the biochemical peculiarities of energy generation in tissue repair. This group was the core of Pathochemistry Laboratory, founded in 1979. In 1982, the Laboratory was integrated into the structure of the Central Research Laboratory. Extending their scientific research, in 1983 some of the scientists assigned to the independent Laboratory of Physical and Chemical Research, renamed in 1988 into Laboratory of Clinical Chemistry. In 1992, the laboratories merged into the Laboratory of Pathochemistry of Institute for Biomedical Research. In 2011, the Laboratory of Pathochemistry was reorganized into the Laboratory of Molecular Neurobiology of Neuroscience Institute.
Title: The role of the oxidative stress in aging
The aging appears to be one of the main reasons causing many of neurodegenerative diseases.This study is intended to evaluate the changes of the antioxidant defence system activity in the brain and other organs, during aging and to answer the question whether natural antioxidants are good for healthy aging. It is planned to assess the antioxidant defence system activity and lipid peroxidation of the laboratory animals of different ages; to determine the biochemical mechanisms of the impact of prooxidants in animal organs; to assess the effects of natural antioxidants on the cellular antioxidant defence system; and to evaluate the apoptosis in the organs of different ages animals, exposed to either prooxidants and antioxidants.
The results will be important both for researchers, working in the field of gerontology and for pharmaceutical specialists, developing natural medicines and supplements known to have antioxidant properties.
2018-2020 – contribute (dr. A.Jekabsone) in the project No J05-LVPA-K-01-0220 „Promotion of UAB "Birštono mineraliniai vandenys" Investment in R&D Activities for the Development of Innovative Products“, head prof. V.Lesauskaitė
2017-2021 – a project No 01.2.2-LMT-K-718-01-0036 EXOTARGET „Exosome application for targeted drug delivery“, funded by the Research Council of Lithuania, head dr. A.Jekabsone
2017-2020 – EU funded COST Action project CA16122 "Biomaterials and advanced physical techniques for regenerative cardiolgy and neurology", dr. A.Jekabsone
2017-2019 – contribute (dr. A.Jekabsone) in the EC programme Horizon 2020 M-Era.Net project No S-M-ERA.NET-17-2 „Engineering and functionalization of delivery system with Pelargonium sidoides biologically active substance on inflamed periodontal surface area“ (PELARGODONT), coordinator prof. N.Savickienė
Institute of Public Health and Environment (Bilthoven, The Netherlands), University of Aarhus (Denmark), University of New York (USA).
2018 - 2011 main publications
Updated on 1 October 2019
Laboratory of Molecular Neurooncology
Adress:Laboratory of Molecular NeurooncologyNeuroscience InstituteLithuanian University of Health SciencesEiveniu st. 4Kaunas LT-50161Lithuania Phone: +370 37 326769Fax: +370 37 795482
Head of Laboratory:
Kęstutis Skauminas, M.D., PhD
Phone +370 37 326883
prof. Vytenis Pranas Deltuva, M.D. PhD, firstname.lastname@example.org
Arūnas Kazlauskas, PhD, email@example.com
Daina Skiriutė, PhD, firstname.lastname@example.org
Giedrius Steponaitis, PhD, email@example.com
Rūta Urbanavičiūtė, PhD student, firstname.lastname@example.org
Indrė Valiulytė, PhD student, email@example.com
Rytis Stakaitis, PhD student, firstname.lastname@example.org
Jūratė Žeglienė, email@example.com
Raminta Bagdanavičienė, firstname.lastname@example.org
Saulius Tacionis, email@example.com
Laboratory short history
The Laboratory of Neurosciences was established on April 28th 1978, as a sub-division of the Oncology Scientific-Research Institute, Ministry of Health Care. The task of Laboratory was to organize additional scientific research to analyze the central regulation of brain and systematic blood circulation. In the structure of Oncology Institute, it was referred to as the Nervous System Surgery Department while Department of Neurosurgery of Kaunas Medicine Institute Clinics was appointed as its clinical basis. In due course, namely in 1982, the Laboratory moved from Oncology Institute to Central Scientific-Research Laboratory of Kaunas Medicine Institute and was renamed into Nervous System Surgery Laboratory. In 2005 the Laboratory was renamed into the Laboratory of Neurosciences and in 2011, after reorganisation, Laboratory got the name of Neurooncology and Genetics, and functions in the structure of Neuroscience Institute of Lithuanian University of Health Sciences. In 2011 Laboratory got the name of Neurooncology and Genetics and in 2018, after reorganisation, got the name of Molecular Neurooncology .
Title: Research on molecular markers and etiopathogenesis of rare CNS diseases for optimisation of diagnosing and treatment
The main trends of research work are: research of clinical, etiopathogenetic, radiological factors, playing a decisive role in the course of CNS tumours and the accumulation of pathological material for the investigation for new combinations of clinical genetic and epigenetic markers in diagnosis and prognosis, research on diagnostic molecular markers in glioblastoma and pituitary adenoma, optimisation of the surgical diagnosing of cerebral gliomas using innovative optical technologies.
The main goal of these studies is to estimate the complex of molecular markers (projects GREAT and GlioPRoSer) and clinical factors valuable for rare CNS diseases diagnosis and prognosis, to identify molecular factors that are responsible for the initiation of cancerogenesis in CNS cells (project "Novel systems of prodrug activation for the cancer gene therapies") and to evaluate the possibilities of combination of intraoperative tissue identification methods by segmentation of intraoperative magnetic resonance, 3D ultrasound and fluorescence images for optimal visualization of brain tumours.
Objectives: with the use of cell culturing facilities, to develop procedures necessary for isolation, cultivation and identification of glioma tumour stem cells (GTSC) and by using a number of molecular biology techniques such as Western blot analysis, real-time PCR, and protein co-precipitation, to investigate the composition of transcription regulatory complexes of genes that determine invasiveness of GTSCs. Enlarge picture:
Research on epigenetic alterations (DNA methylation, chromatine modifications, miRNAs, etc.) of genes associated with oncogenesis, invasion and resistance to therapy of glioblastoma; research on association between gene epigenetic alterations and gene expression (at mRNA and protein level) in glioblastoma tissue; investigation of the influence on certain gene expression and function of epigenetic promoter alterations (DNA methylation, chromatine remodeling), caused by in vitro manipulating cell culture; selection on the relevance of epigenetic alterations and gene expression diagnostically meaningful genes or gene complexes in glioblastoma and pituitary adenoma. Employing three imaging modalities there will be created methodology for coregistration of 3D interlinked information. There will be investigated methods for quantification and segmentation of FS, US and MRI images. Processing of interrelated images is planned to implement in optimised algorithms to support tissue discrimination.
The information and experience obtained from this research could be used for developing new diagnostic methods and developing a methodology for the search for new therapeutic agents against rare CNS diseases.
2019 – a project "Investigation of promoter methylation of metallothioneine genes MT1A, MT1E, MT1G, and MT1M in gliomas", funded through the Research Council of Lithuania, head dr. D.Skiriutė
2019 – a project "Generation of stable U87 cell line coding inducible Sema3F expression system", funded through the Research Council of Lithuania, head I.Valiulytė
2019 – a project "Construction of a bicistronic vector for immortalization of human vascular endothelial cells", funded through the Research Council of Lithuania, head dr. A.Kazlauskas
2018 – a project "NRP1 gene expression in different grade gliomas", funded through the Research Council of Lithuania, head I.Valiulytė
2018 – a project "Long-non coding RNA HOTAIR and CASC2 gene expression in glioblastomas", funded through the Research Council of Lithuania, head dr. D.Skiriutė
2017-2021 – contribute (dr. A.Kazlauskas, dr. G.Steponaitis) in the project No 01.2.2-LMT-K-718-01-0036 EXOTARGET „Exosome application for targeted drug delivery“, funded by the Research Council of Lithuania, head dr. A.Jekabsone
2017-2020 – a project No S-MIP-17-108 "The prognostic value of miRNA classifier as a novel tool for prediction of glioma patient outcome and response to therapy", funded by the Research Council of Lithuania, dr. P.Vaitkienė
2015-2018 – collaboration (dr. A.Kazlauskas) in the project No SEN-07/2015 „Novel systems of prodrug activation for the cancer gene therapies“, of the National Programme "Healthy Aging" funded by the Research Council of Lithuania, head dr. J.Urbonavičius (VU)
2015-2018 – a project "New genetic and metabolic biomarkers search in healthy subjects and patients with age-related macular degeneration", funded by the Research Council of Lithuania, head prof. V.P.Deltuva
2015-2018 – a project GlioProSer "Quantitative serum profiles estimation of proteins related to glioma angiogenesis and invasiveness”, funded by the Research Council of Lithuania, head dr. D.Skiriutė
2014-2016 – contribute in the project No MIP-008/2014 "New molecular prognostic markers search in pituitary adenomas and associations with visual functions", funded by the Research Council of Lithuania, head prof. D.Žaliūnienė
2014-2015 – collaboration in the Lithuanian-Ukrainian project "Identification and characterization of novel biomarkers for human glial tumors", head dr. P.Vaitkienė
2012-2015 – contribute (dr. D.Skiriutė) in the Global grant project* No VP1-3.1-ŠMM-07-K-02-060 „Gene-Environment Interactions Connecting Low Triiodothyronine Syndrome and Outcomes of Cardiovascular Disease (GET-VASC)”, head prof. R.Bunevičius
2012-2014 – a project No LIG-12003 "Gene expression and function-based identification of biomarkers for diagnosis of glioma malignancies", funded by the Research Council of Lithuania, head dr. A.Kazlauskas
2010-2011 –a project “Low T3 syndrome impact on the outcomes after the brain tumour surgery”, funded by the Research Council of Lithuania, head dr. V.P.Deltuva
2010-2011 – a project „The investigation for new combinations of clinical and epigenetic markers in diagnosis and prognosis“, funded by the Research Council of Lithuania, head prof. A.Tamašauskas
2007-2009 – post doc (dr. D.Skiriutė) project "Research on molecular markers of recurrence in benign and malignant meningiomas", funded by Lithuania State Science and Studies Foundation, head prof. A.Tamašauskas
2006-2008 – ESF project No ESF/2004/2.5.0-03-385/BPD-210/ES2006-01 "Implementation of advanced studies for medical physics technologies and nanophotonics", dr. K.Skauminas
2006-2008 – ESF project No BPD2004-ERPF-1.5.0-12-05/0035 “Centre for science and studies of medical physics technologies and nanophotonics”, dr. K.Skauminas
2006 – a project “Intraoperative fluorescentic imaging of brain tumour gliomas”, funded by Lithuania State Science and Studies Foundation
2019.04.01-06.30 – I. Valiulytė traineeship at the University Hospital Essen, Department of Neurosurgery, Molecular Biology Research Laboratory (Essen, Germany), head prof. Yuan Zhu
2017.09.28-12.27 – R.Urbanavičiūtė traineeship at the German Cancer Research Center (DKFZ), Clinical Cooperation Unit Neuropathology (Heidelberg), head dr. Stefan Pusch
2015.01.15-06.01 – dr. D.Skiriutė traineeship at the Debrecen University (Hungary), Department of Biochemistry and Molecular Biology, Centre of Clinical Genomics and Personalised Medicine, head dr. Balint Laszlo Balint
2014.09.17-09.27 – G.Steponaitis traineeship at National Academy of Sciences of Ukraine, Institute of Molecular Biology and Genetics, Department of Biosynthesis of Nucleic Acids, head prof. V.M.Kavsan
2013.02-2013.05 – G.Steponaitis Erasmus funded traineeship at University of Helsinki, Haartman Institute, Department of Virology, Kalle Saksela laboratory, head prof. Kalle Saksela
2018 - 2011 main publications
Updated on 9 September 2019
Laboratory of Neurophysiology
Address:Laboratory of NeurophysiologyNeuroscience InstituteLithuanian University of Health SciencesEiveniu st. 4Kaunas LT-50161Lithuania
Phone number: +370 37 302958
Head of the laboratory:
Gytis Svirskis, PhD, firstname.lastname@example.org
Gytis Baranauskas, PhD, email@example.com
Nataša Svirskienė, PhD, firstname.lastname@example.org
Gražina Grebliauskienė, email@example.com
Laboratory short history
Laboratory of Neurophysiology continues research themes started earlier by three previous neuroscience laboratories. In 1957, Laboratory of EEG in Kaunas Institute of Medicine was created. Later, Laboratory of Neurophysiology and Laboratory of Neurocybernetics were created. Scientific research was carried out in several directions: experimental – investigating the nature of high and low frequency biocurrents in the brain; pharmacological – investigating influence of pharmacological substances on biocurrents; theoretical – investigating biophysical nature of brain potentials and properties of dendrites with nonlinear electrical properties; clinical – investigating EEG, neurological characteristics and activity spreading pathways in epilepsy and other brain injuries. Since then 21 PhD and 5 Habil. Sc. dissertations were prepared and defended in these laboratories.
Title: Investigation of neural network mechanisms and their relationship to behaviour
Identification of the relation between neuronal activity and behaviour is necessary in order to understand the function and pathology of the nervous system. Since Alzheimer disease disrupts collision detection, the study of neuronal mechanisms of this behaviour could be important in early detection of the disease. We will study neuronal network spontaneous and induced activity in in vitro and in vivo mammalian cortex, colliculus superior and frog tectum by applying visual stimulation, neuronal registration and methods of molecular biology.
The investigation will aim at elucidation of synaptic and membrane mechanisms of neuronal network spontaneous and evoked activity.
2019-2022 – a project No P-MIP-19-138 "'The role of neuronal networks in the superior colliculus in rapid recognition of complex images", funded by the Research Council of Lithuania, head dr. G.Baranauskas
2017-2021 – contribute (dr. G.Svirskis, dr. N.Svirskienė) in the Global grant project No LMT-K-712-01-0131 "Dissecting ischemic brain injury: role of mitochondrial permeability transition pore in cells of developing and aging brain", head prof. V.Borutaitė
2012-2015 – Global grant project* No VP1-3.1-ŠMM-07-K-02-059 „Investigation of sensory information processing and attention mechanisms by employing genetic modification of neuronal act", head dr. T.Tkatch
2012-2014 – a project No MIP-045/2012 „Nicotinic modulation of neuronal column activity", funded by the Research Council of Lithuania, head habil.dr. A Kuras
2012-2014 – ESF project No VP1-3.1-ŠMM-08-K-01-022 „Implementation of R&D activities of Medicine National Research Programmes in clinical and molecular research of fundamental cardiology, neurosciences, and digestive systems“, dr. G.Svirskis, prof. V.Borutaitė
2011-2012 – a project No MIP-11298 “Interactions between tectal neuronal responses evoked by two visual stimuli”, funded by the Research Council of Lithuania, head dr. G.Svirskis
2010-2011 – a project „Investigation of synaptic co-transmission in frog retinotectal synapses“, funded by the Research Council of Lithuania, head habil.dr. A.Kuras
2008 – a project “Implication of bistability of frog recurrent tectal neurons in the activation of NMDA receptors”, funded by Lithuania State Science and Studies Foundation, head habil.dr. A.Kuras
2007 – a project “Investigation of dendritic currents elicited in frog tectum neurons by individual retinotectal input”, funded by Lithuania State Science and Studies Foundation, head habil.dr. A.Kuras
2005 – a project “Investigation of influence of frog moving-edge detector on tectal neuron network”, funded by Lithuania State Science and Studies Foundation, head habil.dr. A.Kuras
2004 – a project „NMDA receptor activation in frog tectum neurons“, funded by Lithuania State Science and Studies Foundation, head habil.dr. A.Kuras
Copenhagen University (Denmark), New York University (USA), University of Oslo (Norway).
2018 - 2011 main publications
Updated on 3 June 2019
Laboratory of Toxicology
Address:Laboratory of ToxicologyNeuroscience InstituteLithuanian University of Health SciencesEiveniu st. 4Kaunas LT-50161Lithuania
Phone: +370 37 302948
Head of the laboratory:
Rima Naginienė, PhD, firstname.lastname@example.org
Loreta Strumylaitė, PhD, email@example.com
Rima Kregždytė, PhD, firstname.lastname@example.org
Dalė Baranauskienė, PhD, email@example.com
Jurgita Šulinskienė, PhD, firstname.lastname@example.org
Vaida Šimakauskienė, email@example.com
Arvydas Laukevičius, firstname.lastname@example.org
Gabrielė Janušauskaitė, email@example.com
Lionė Grabauskienė, firstname.lastname@example.org
Aldona Švėgždienė, email@example.com
Laboratory short history
Laboratory of Toxicology (from 2011-07-01 till 2018-01-01 was Laboratory of Neurotoxicology) was established in 2011 via reorganization of the Laboratory for Environmental Health Research. The latter Laboratory was established in 2005 after merger of Laboratory for Anthropogenic Factors Research and Laboratory of Ecological Monitoring of Human Health. These laboratories were established in 1989 for implementation of Lithuanian State Program of Ecological Monitoring. Researchers of the Laboratory were innovators in Lithuania of heavy metals and trace elements investigation and assessment in various biological media (human hair, blood, urine, and biopsy material, experimental animals, etc). The focus of Laboratory research is investigation of trace elements and their biomarkers in connection with public health, occupational health, and clinical research (e.g. trace elements equilibrium in patients with chronic kidney insufficiency, manganese as prognostic value of hepatic encephalopathy, disorders of copper metabolism in patients with Wilson’s disease, involvement of cadmium in pathogenesis of breast cancer, etc.).
There were 9 PhD thesis defended at the Laboratory during 1989-2011.
Title: The role of trace elements in pathogenesis and prevention of brain tumours
Glioblastomas are the most common and the most aggressive malignant primary brain tumours in humans. In spite of multiple therapies the survival rate is only 12-14 months after diagnosis. These tumours are resistant to treatment and frequently implicate multidrug resistance phenotype. The mechanisms are not fully understood though it is known that metallothioneins (MT) might be involved in forming multidrug resistance. Metallothioneins are intracellular low molecular weight proteins, MTs function is not clear, but experimental data suggest MTs may provide protection against heavy metal toxicity, be involved in regulation of physiological metals (Zn and Cu) and provide protection against oxidative stress. The MT expression in some tumours correlates with degree of malignancy and tumour growth rate. It is established that single nucleotide polymorphism SNP of the gene MT2A is involved in accumulation of Cd, bioaccessibility of Zn, and Mg and Fe amount in blood. Therefore, the data on relation between trace elements, metallothioneins and MT gene polymorphism are lacking.
2017-2021 – contribute (dr. L.Strumylaitė) in the EC programme Horizon 2020 funded project No 733032 HBM4EU (The European Human Biomonitoring Initiative)
2013-2015 – contribute (dr. R.Naginienė) in the Global grant project* No VP1-3.1-ŠMM-07-K-02-060 „Gene-Environment Interactions Connecting Low Triiodothyronine Syndrome and Outcomes of Cardiovascular Disease (GET-VASC)”, head habildr. R.Bunevičius
2009 – a project No T-64/09 "The assessment of the relationship between cadmium and the risk of breast cancer", funded by Lithuania State Science and Studies Foundation, head dr. L.Strumylaitė
2007-2009 – EC 6FP project SSPE-CT-2007-044159 PRONET (Pollution Reduction Options Network), Lithuania deputy dr. R.Naginienė
2005-2007 – Implementation of the EU Council Directive 77/312EEB on Biological Screening of the Population for Lead, dr. R.Naginienė
2003-2005 – EC 5FP project QLK4-2002-02395 PINCHE (Policy Interpretation Network on Children’s Health and Environment), Lithuania deputy dr. R.Naginienė
Since 2006, the Laboratory is Lithuanian Satellite Centre of Trace Element Institute for UNESCO.
2018 - 2011 main publications
Updated on 22 May 2019
Laboratory of Ophthalmology
Address:Laboratory of OphthalmologyNeuroscience InstituteLithuanian University of Health SciencesEiveniu st. 4Kaunas LT-50161Lithuania Phone: +370 37 326749
Head of the laboratory
Rasa Liutkevičienė, PhD, firstname.lastname@example.org
Loresa Kriaučiūnienė, PhD, email@example.com
Alvita Vilkevičiūtė, PhD student, firstname.lastname@example.org
Greta Gedvilaitė, email@example.com
Kristė Kaikarytė, firstname.lastname@example.org
Laboratory short history
Laboratory was established in 1992. The areas of scientific research are: epidemiologic investigation of eye diseases; complex ultrasonic investigation of structure, dimensions and haemodynamics of ocular tissue; storing and processing of ophthalmological images and signals for interactive and automatic multi-criterial clinical decision support. During collaboration with Sweden, Holland, Brazil in international E-Health and Telemedicine projects, infrastructure for scientific research in virtual environment was established. In 2003 Telemedicine centre of Kaunas University of Medicine (Lithuanian University of Health Sciences since 2011) was established, that is now institutional member of International Society for Telemedicine and e-Health (ISfTeH).
In the Laboratory 12 doctoral dissertations have been defended.
The Laboratory was awarded with eEurope Award for e-Health 2003 “e-Health NetLit (LT)" - a Finalist Diploma in a High Level Conference and Exhibition on e-Health, Brussels, 22, 23 April 2003.
Title: Relation of the eye neurosensoric function to genotype and fenotype in age related macular degeneration
Age related macular degeneration (AMD) – age related neurodegenerative disease of macula – central part of the retina. It leads to considerable visual loss. AMD is one of main causes of blindness in people in age over 60. Because of progressive loss of central visual function, it has marked influence to patient behaviour and life quality. In 2002 in Lithuania was 13.8% blind people because of AMD. In 2020 the amount of handicapped people because of AMD will increase to 16.5%. Unfortunately, today AMD is not treatable. However, up to now there is no proper treatment for age-related macular degeneration though novel treatment methods can stop progression of AMD and to help avoid blindness. That is why new information about pathogenesis of AMD can support development of the new methods of treatment and prevention of this disease.
Diagnosis, observation of course and treatment of AMD needs high resolution imaging technologies, parameterisation and high skilled ophthalmologist evaluation. Quantitative evaluation of this visual information could be achieved using biophysical models based imaging and quantitative evaluation methods.
Researchers of Laboratory of Ophthalmology in collaboration with Laboratory for Biophysics and Bioinformatics are planning to collaborate for biophysical models based biomedical signal and image analysis methods to process a big amount of information from biomedical signals, images, clearing up changes in eye neurosensoric function in AMD and reflecting the relation to genetic polymorpfisms. For this purpose some genetic markers (MMP-2 -1306C/T and -735C/T, MMP-3, -1171 5A/6A, MMP-9 -1562C/T, ApoE) will be investigated.
2016-2017 – collaboration (dr. R.Liutkevičienė) in the LSMU-KTU project "Elaboration and employment of virtual reality stimuli to investigate peripheral vestibular function employing innovative device (VIRVEST)", head prof. I.Ulozienė
2015-2018 – a project No SEN-11/2015 "New genetic and metabolic biomarkers search in healthy subjects and patients with age-related macular degeneration", funded by the Research Council of Lithuania, head prof. V.P.Deltuva
2015-2016 – collaboration in the Lithuanian-Japan project "Analysis of biomarkers discovered by using S.Pombe in human blood", dr. R.Liutkevičienė
2014-2016 – contribute (dr. R.Liutkevičienė) in the project No MIP-008/2014 " New molecular prognostic markers search in pituitary adenomas and associations with visual functions", funded by the Research Council of Lithuania, head prof. D.Žaliūnienė
2014-2015 – collaboration (dr. R.Liutkevičienė) in the LSMU-KTU project "Elaboration of innovative device to investigate peripheral vestibular function", head prof. I.Ulozienė
2013-2015 – post doc (dr. Asta Kybartaitė-Žilienė) project BioMONDA "Multimodal data analysis of optic nerve and it's environment based on biophysical models", funded by the Research Council of Lithuania, head prof. A.Kriščiukaitis
2018 - 2011 main publications
Updated on 22 May 2019
Laboratory for Research of Pharmacological Regulation of Pathological Processes and Drug Metabolism
Address:Laboratory for Research of Pharmacological Regulation of Pathological Processes and Drug MetabolismNeuroscience InstituteLithuanian University of Health SciencesEiveniu st. 4Kaunas LT-50161Lithuania
The Laboratory for Research of Pharmacological Regulation of Pathological Processes and Drug Metabolism funcions in the Advanced Pharmaceutical and Health Technologies Centre of Lithuanian University of Health Sciences.
Updated on 29 January 2019