Use this url to cite publication: https://hdl.handle.net/20.500.12512/92962
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CAG and GGN repeats in AR gene exert combinatorial effects on reproductive parameters in Baltic young male cohort / Marina Grigorova, Margus Punab, Tiina Kahre, Mare Ivandi, Neeme Tõnisson, Olev Poolamets, Vladimir Vihljajev, Birutė Žilaitienė, Juris Erenpreiss, Valentinas Matulevičius, Maris Laan
Type of publication
Konferencijų tezės nerecenzuojamame leidinyje / Conference theses in non-peer-reviewed publication (T2)
Author(s)
Grigorova, Marina | Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia |
Punab, Margus | Tartu University Clinics, Tartu, Estonia |
Kahre, Tiina | Tartu University Hospital, Tartu, Estonia |
Ivandi, Mare | Tartu University Hospital, Tartu, Estonia |
Tõnisson, Neeme | Tartu University Hospital, Tartu, Estonia |
Poolamets, Olev | Tartu University Clinics, Tartu, Estonia |
Vihljajev, Vladimir | Tartu University Clinics, Tartu, Estonia |
Erenpreiss, Juris | Riga Stradins University, Rīga, Latvia |
Laan, Maris | Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia |
Title
CAG and GGN repeats in AR gene exert combinatorial effects on reproductive parameters in Baltic young male cohort / Marina Grigorova, Margus Punab, Tiina Kahre, Mare Ivandi, Neeme Tõnisson, Olev Poolamets, Vladimir Vihljajev, Birutė Žilaitienė, Juris Erenpreiss, Valentinas Matulevičius, Maris Laan
Publisher (trusted)
Centre of Genetics and Biotechnology Omicum |
Date Issued
Date Issued |
---|
2015-23-04 |
Extent
p. 16.
Is part of
“Pre- and perinatal determinants of health in child-and adulthood” : Abstract book of the international course, April 23-24, 2015, Tartu, Estonia / Centre of Genetics and Biotechnology Omicum. Tartu : Doctoral School of Clinical Medicine, 2015.
Version
Originalus / Original
Series/Report no.
Oral presentations
Field of Science
Abstract
Objectives: The androgen receptor (AR) mediating androgen action is primarily involved in sexual differentiation during embryogenesis, growth of accessory sex organs as well as normal sperm production. Androgen receptor gene (AR) harbours two polymorphic polyglutamine (CAG) and polyglycine (GGN) repeat motifs. We aimed to study individual and combinatorial effect of CAG and GGN repeats on hormonal and testicular parameters in Baltic male cohort. Material and methods: Baltic young male cohort (n=974, 20.1±2.0 yrs, sperm conc. 81.6±73.0 mln/mL); genotyping of CAG and GGN repeats by fluorescently‐labelled PCR; linear regression (CAG and GGN repeat lengths as continuous variables), one‐way analysis of covariance (ANCOVA, CAG and GGN trichotomised as short, medium, and long (i.e., CAG≤21, 22≤CAG≤24, CAG≥25; GGN≤22, GGN=23, GGN≥24), and treated as categorical variables), adjustment for confounders; Mann‐Whitney U‐ (M‐W) and Kruskal‐Wallis (K‐W) tests in the groups of trichotomised CAG and GGN lengths as well as in nine groups of the combinations of short (s), medium (m), and long (l) CAG and GGN repeats (i.e., lCAG–sGGN = long CAG–short GGN, etc.). Results and Conclusion: The median (range) of CAG and GGN repeat lengths were 23 (13‐33) and 23 (9‐28), respectively. Significant positive correlation was identified between CAG and GGN repeats (Pearson's r=0.142, p<0.0001). Men with longer CAG repeat length had significantly lower serum FSH (linear model p=0.002, β=-‐0.056 IU/L; sCAG vs lCAG, mean(median), 3.24(2.92) vs 2.94(2.53) IU/L, M‐W p=0.014) accompanied with non‐significantly lower sperm concentration (sCAG vs lCAG, 89.0(71.6) vs 80.0 (62.9) mln/mL, M‐W p=0.061). Longer GGN repeats were significantly associated with lower sperm concentration (sGGN vs lGGN, 91.3(68.4) vs 76.2 (60.2) mln/mL, M‐W p=0.027). [...].
Type of document
type::text::conference output::conference proceedings::conference paper
Other Identifier(s)
(LSMU ALMA)990000866690107106
Coverage Spatial
Estija / Estonia (EE)
Language
Anglų / English (en)