Use this url to cite publication: https://hdl.handle.net/20.500.12512/117048
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Thyroid hormones and health related quality of life in normal pressure hydrocephalus patients / Mindaugas Urbonas, Nijole Raskauskiene, Vytenis Pranas Deltuva, Adomas Bunevicius
Type of publication
Tezės Web of Science ir Scopus duomenų bazėje / Theses in Web of Science and Scopus database (T1a)
Author(s)
Title
Thyroid hormones and health related quality of life in normal pressure hydrocephalus patients / Mindaugas Urbonas, Nijole Raskauskiene, Vytenis Pranas Deltuva, Adomas Bunevicius
Publisher (trusted)
Date Issued
Date Issued |
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2022-09-09 |
Extent
p. 13-13.
Is part of
Fluids and Barriers of the CNS - FBCNS. Supplements : Abstracts from Hydrocephalus 2022: the Fourteenth Meeting of the Hydrocephalus Society : Gothenburg, Sweden, 9-12 September 2022 : meeting abstracts. London : Biomed Central, 2022, vol. 19, suppl. 1.
Version
Originalus / Original
Description
Field of Science
Abstract
Introduction: This study evaluated the changes of thyroid hormones in iNPH patients before and after the ventriculoperitoneal shunting. We also sought to ascertain whether shunt implantation would result in the improvement of thyroid function and depression and anxiety. Methods: Serum levels of FT3, FT4 and TSH were analysed among iNPH patients preoperatively, postoperatively and 3-months after the ventriculoperitoneal shunting. Preoperative FT3/FT4 ratio and its effect on outcome measured by PHQ-9 and GAD-7 preoperatively and 3-months after the shunting were analysed. Results: 25 patients were included (52% women, mean age63.5(SD9.5) years. Median Evan’s index was 0.42 (range 0.34–0.56).Preoperative Evan’s index was related to FT3 (r=0.504, p=0.017). The median (range) of preoperative FT3 and FT4 were 3.68 (3.24–4.47) and15.48 (14.47–17.97) pmol/L, respectively. The median of TSH was 1.09(0.24–4.79) mIU/L. FT3 levels were below normal value (<3.34 pmol/L)in 24%, 64.5%, and 8% of the patients preoperatively, postoperatively and 3-months after the shunting, respectively (p<0.001). When comparing preoperative and postoperative thyroid hormone profiles, significant decrease occurred in FT3 and TSH, while FT4 increased significantly (all p<0.001). 3-months after the shunting thyroid hormones restored to the normal range. Preoperative higher FT3/FT4 ratio related to a poor 3-months outcome in depression (PHQ-9) and anxiety (GAD-7). The reported 3-months positive outcome rate in terms of depression and anxiety was 75%.Conclusion: Our study demonstrated that some deficiencies of hypothalamic-pituitary-thyroid axis may improve at 3-months after the ventriculoperitoneal shunting among patients with iNPH. Increased preoperative FT3/FT4 ratio was associated with reduced quality of life.
Type of document
type::text::conference output::conference proceedings::conference paper
ISSN (of the container)
2045-8118
2045-8118
WOS
000927885100043
Other Identifier(s)
(LSMU ALMA)991693887107106
Coverage Spatial
Švedija / Sweden (SE)
Language
Anglų / English (en)
Funding(s)
Funding(s) |
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Hydrocephalus Society |
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
Fluids and Barriers of the CNS | 7.3 | 4.6 | 4.6 | 4.6 | 1 | 1.587 | 2022 | Q1 |
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
Fluids and Barriers of the CNS | 7.3 | 4.6 | 4.6 | 4.6 | 1 | 1.587 | 2022 | Q1 |
Journal | Cite Score | SNIP | SJR | Year | Quartile |
---|---|---|---|---|---|
Fluids and Barriers of the CNS | 9.4 | 1.772 | 1.657 | 2022 | Q1 |