Use this url to cite publication: https://hdl.handle.net/20.500.12512/108070
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Characterization of Helicobacter pylori Infection in the upper gastrointestinal tract of twins / R. Vilchez-Vargas, J. Skieceviciene, J. Arstikyte, M. Urba, C. Thon, D. Schanze, M. Zenker, P. Malfertheiner, J. Kupcinskas, A. Link
Type of publication
Tezės Web of Science duomenų bazėje / Theses in Web of Science database (T1a1)
Author(s)
Vilchez-Vargas, Ramiro | Otto-von-Guericke University Hospital Magdeburg, Magdeburg, Germany |
Thon, Cosima | Otto-von-Guericke University Hospital Magdeburg, Magdeburg, Germany |
Schanze, Denny | Otto-von-Guericke University Hospital Magdeburg, Magdeburg, Germany |
Zenker, Martin | Otto-von-Guericke University Hospital Magdeburg, Magdeburg, Germany |
Malfertheiner, Peter | Otto-von-Guericke University Hospital Magdeburg, Magdeburg, Germany |
Link, Alexander | Otto-von-Guericke University Hospital Magdeburg, Magdeburg, Germany |
Title
Characterization of Helicobacter pylori Infection in the upper gastrointestinal tract of twins / R. Vilchez-Vargas, J. Skieceviciene, J. Arstikyte, M. Urba, C. Thon, D. Schanze, M. Zenker, P. Malfertheiner, J. Kupcinskas, A. Link
Publisher (trusted)
Date Issued
2020-09-12
Extent
p. 77-78.
Is part of
Helicobacter : Special Issue: The Year in Helicobacter. EHMSG – 33rd International Workshop on Helicobacter & Microbiota in Inflammation & Cancer : Virtual Conference September 10-12, 2020, Glasgow, United Kingdom : Accepted Abstracts / European Helicobacter and Microbiota Study Group ; Guest editors: Francis Mégraud & Peter Malfertheiner. Oxford : Wiley-Blackwell, 2020, vol. 25, suppl. 1.
Version
Originalus / Original
Description
no. EP6.15
Electronic poster round 6: microbiology and genomics of helicobacter EP6.01 | Changes in the fluoroquinolone resistance of Helicobacter pylori over a 14-year period and discovery of a novel mutation in DNA gyrase: A single center study in Korea.
Field of Science
Abstract
Introduction: Helicobacter pylori (H. pylori) is an infectious disease that causes chronic gastritis, may contribute to development of preneoplastic mucosal alterations and also leads to development of peptic ulcer disease and gastric cancer. Characterization of microbiota in monozygotic and heterozygotic twins may offer a unique model to understand their contribution to H. pylori induced gastroduodenal pathologies (but is still insufficiently utilized). Methods: In this study, we characterized bacterial communities from saliva of 20 twin pairs, upper GI tract of 25 twin pairs and feces from 99 twin pairs (total 288 samples) by high throughput sequencing. Results: H. pylori was only detected in gastric corpus and antrum mucosa but not in saliva or feces. Among twins with discordant H. pylori status, we observed no correlation between gastric microbiome and the presence of H. pylori infection. However, among the 9 twins with concordant H. pylori positivity, there were 5 twins with the same clone of H. pylori infection while in 4 twins the subspecies were different in comparison to paired twin siblings. Conclusions: Our preliminary results strongly suggest that H. pylori is the most predominant factor that may influence stomach microbiome of the twins. Differences in H. pylori phylotypes suggest that H. pylori might be acquired from heterogeneous source during the childhood and lifetime. Further investigations are being carried out to characterize the microbiome of saliva and the lower GI tract from twins.
Type of document
type::text::conference output::conference proceedings::conference paper
ISSN (of the container)
1083-4389
1523-5378
WOS
000718356300135
Other Identifier(s)
(LSMU ALMA)990001017010107106
Coverage Spatial
Jungtinė Karalystė / United Kingdom of Great Britain and Northern Ireland (GB)
Language
Anglų / English (en)
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
HELICOBACTER | 5.753 | 5.703 | 5.079 | 6.327 | 2 | 1.043 | 2020 | Q1 |
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
HELICOBACTER | 5.753 | 5.703 | 5.079 | 6.327 | 2 | 1.043 | 2020 | Q1 |
Journal | Cite Score | SNIP | SJR | Year | Quartile |
---|---|---|---|---|---|
Helicobacter | 7.4 | 1.5 | 1.206 | 2020 | Q1 |