Use this url to cite publication: https://hdl.handle.net/20.500.12512/105737
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Systematic review: gastric microbiota in health and disease / Mirjana Rajilic-Stojanovic, Ceu Figueiredo, Annemieke Smet, Richard Hansen, Juozas Kupcinskas, Theo Rokkas, Leif Andersen, Jose C. Machado, Gianluca Ianiro, Antonio Gasbarrini, Marcis Leja, Javier P. Gisbert, Georgina L. Hold
Type of publication
Straipsnis Web of Science duomenų bazėje / Article in Web of Science database (S1a)
Author(s)
Rajilic-Stojanovic, Mirjana | University of Belgrade, Belgrade, Serbia |
Figueiredo, Ceu | Institute of Molecular Pathology and Immunology of the University of Porto, Instituto de Investigação e Inovação em Saúde, and Faculty of Medicine of the University of Porto, Porto, Portugal |
Smet, Annemieke | Laboratory of Experimental Medicine and Pediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium |
Hansen, Richard | Royal Hospital for Children, Glasgow, UK |
Rokkas, Theodore | Henry Dunant Hospital, Athens, Greece |
Andersen, Leif P | Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark |
Machado, José Carlos | Instituto de Investigação e Inovação em Saúde, Universidade do Porto, and Ipatimup – Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal |
Ianiro, Gianluca | Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
Gasbarrini, Antonio | Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy |
Leja, Mārcis | Institute for Clinical and Preventive Medicine, University of Latvia, Riga, Latvia |
Gisbert, Javier Perez | Gastroenterology Unit of Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid, and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain |
Hold, Georgina Louise | University of New South Wales, Sydney, NSW, Australia |
Title
Systematic review: gastric microbiota in health and disease / Mirjana Rajilic-Stojanovic, Ceu Figueiredo, Annemieke Smet, Richard Hansen, Juozas Kupcinskas, Theo Rokkas, Leif Andersen, Jose C. Machado, Gianluca Ianiro, Antonio Gasbarrini, Marcis Leja, Javier P. Gisbert, Georgina L. Hold
Publisher (trusted)
Date Issued
2020-02-13
Extent
p. 582-602.
Is part of
Alimentary pharmacology & therapeutics. New York: Wiley, 2020, vol. 51, no. 6.
Version
Originalus / Original
Field of Science
Abstract
Background: Helicobacter pylori is the most infamous constituent of the gastric microbiota and its presence is the strongest risk factor for gastric cancer and other gastroduodenal diseases. Although historically the healthy stomach was considered a sterile organ, we now know it is colonised with a complex microbiota. However, its role in health and disease is not well understood. Aim: To systematically explore the literature on the gastric microbiota in health and disease as well as the gut microbiota after bariatric surgery. Methods: A systematic search of online bibliographic databases MEDLINE/EMBASE was performed between 1966 and February 2019 with screening in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Randomised controlled trials, cohort studies and observational studies were included if they reported next-generation sequencing derived microbiota analysis on gastric aspirate/tissue or stool samples (bariatric surgical outcomes). Results: Sixty-five papers were eligible for inclusion. With the exception of H pyloriinduced conditions, overarching gastric microbiota signatures of health or disease could not be determined. Gastric carcinogenesis induces a progressively altered microbiota with an enrichment of oral and intestinal taxa as well as significant changes in host gastric mucin expression. Proton pump inhibitors usage increases gastric microbiota richness. Bariatric surgery is associated with an increase in potentially pathogenic proteobacterial species in patient stool samples. Conclusion: While H pylori remains the single most important risk factor for gastric disease, its capacity to shape the collective gastric microbiota remains to be fully elucidated. Further studies are needed to explore the intricate host/microbial and microbial/microbial interplay.
Is Referenced by
Type of document
type::text::journal::journal article
ISSN (of the container)
0269-2813
1365-2036
WOS
000513171200001
Other Identifier(s)
(LSMU ALMA)990001003440107106
Coverage Spatial
Jungtinė Karalystė / United Kingdom of Great Britain and Northern Ireland (GB)
Language
Anglų / English (en)
Bibliographic Details
115
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
ALIMENTARY PHARMACOLOGY & THERAPEUTICS | 8.171 | 5.317 | 4.307 | 6.327 | 2 | 1.745 | 2020 | Q1 |
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
ALIMENTARY PHARMACOLOGY & THERAPEUTICS | 8.171 | 5.317 | 4.307 | 6.327 | 2 | 1.745 | 2020 | Q1 |
Journal | Cite Score | SNIP | SJR | Year | Quartile |
---|---|---|---|---|---|
Alimentary Pharmacology and Therapeutics | 14.3 | 2.059 | 3.308 | 2020 | Q1 |